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Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses
Author(s) -
Cheng Sam X.,
Lightfoot Yaíma L.,
Yang Tao,
Zadeh Mojgan,
Tang Lieqi,
Sahay Bikash,
Wang Gary P.,
Owen Jennifer L.,
Mohamadzadeh Mansour
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.05.007
Subject(s) - proinflammatory cytokine , calcium sensing receptor , immune system , intestinal epithelium , inflammation , homeostasis , barrier function , receptor , intestinal mucosa , biology , immunology , epithelium , microbiology and biotechnology , medicine , calcium metabolism , calcium , biochemistry , genetics
The intestinal epithelium is equipped with sensing receptor mechanisms that interact with luminal microorganisms and nutrients to regulate barrier function and gut immune responses, thereby maintaining intestinal homeostasis. Herein, we clarify the role of the extracellular calcium‐sensing receptor (CaSR) using intestinal epithelium‐specific Casr −/− mice. Epithelial CaSR deficiency diminished intestinal barrier function, altered microbiota composition, and skewed immune responses towards proinflammatory. Consequently, Casr −/− mice were significantly more prone to chemically induced intestinal inflammation resulting in colitis. Accordingly, CaSR represents a potential therapeutic target for autoinflammatory disorders, including inflammatory bowel diseases.