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MicroRNA‐106b in cancer‐associated fibroblasts from gastric cancer promotes cell migration and invasion by targeting PTEN
Author(s) -
Yang Ting-Song,
Yang Xiao-Hu,
Chen Xi,
Wang Xu-Dong,
Hua Jie,
Zhou Dong-Lei,
Zhou Bo,
Song Zhen-Shun
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.04.050
Subject(s) - pten , cancer , cancer associated fibroblasts , cancer research , microrna , cancer cell , cell migration , tumor microenvironment , biology , carcinogenesis , cell , medicine , microbiology and biotechnology , signal transduction , pi3k/akt/mtor pathway , gene , genetics
It is well established that the interaction between cancer cells and microenvironment has a critical role in tumor development, but the roles of miRNAs in this interaction are rarely known. Here, we have shown that miR‐106b is up‐regulated in cancer associated fibroblasts compared with normal fibroblasts established from patients with gastric cancer, the expression level of miR‐106b is associated with poor prognosis of patients, and CAFs with down‐regulated miR‐106b could significantly inhibit gastric cancer cell migration and invasion by targeting PTEN. Taken together, these data suggest that miR‐106b might be a novel candidate target for the treatment of gastric cancer.