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The protective effect of CD40 ligand–CD40 signalling is limited during the early phase of Plasmodium infection
Author(s) -
Inoue Shin-Ichi,
Niikura Mamoru,
Inoue Megumi,
Mineo Shoichiro,
Kawakami Yasushi,
Uchida Akihiko,
Ohnishi Hiroaki,
Kamiya Shigeru,
Watanabe Takashi,
Kobayashi Fumie
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.04.035
Subject(s) - cd40 , plasmodium berghei , microbiology and biotechnology , dendritic cell , ligand (biochemistry) , antibody , biology , immunology , immune system , chemistry , receptor , biochemistry , cytotoxic t cell , in vitro , malaria
γδ T cells are essential for eliminating Plasmodium berghei XAT. Because administration of the agonistic anti‐CD40 antibody can induce elimination of P. berghei XAT parasites in γδ T cell‐deficient mice, we considered that γδ T cells might activate dendritic cells via CD40 signalling during infection. Here we report that administration of the anti‐CD40 antibody to γδ T cell‐deficient mice 3–10 days post‐ P. berghei XAT infection could eliminate the parasites. Our data suggest that dendritic cell activation via γδ T cells expressing CD40 ligand is critical during the early phase of infection.