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MicroRNA‐152 targets ADAM17 to suppress NSCLC progression
Author(s) -
Su Yunshu,
Wang Yuchang,
Zhou Hongmin,
Lei Lei,
Xu Lijun
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.04.022
Subject(s) - microrna , gene silencing , suppressor , cancer research , carcinogenesis , cell growth , lung cancer , biology , rna interference , cell , cell culture , cancer , rna , medicine , oncology , gene , genetics
MicroRNAs (miRNAs) are a class of small non‐coding RNAs that have been suggested to play an essential role in tumorigenesis. In this study, we show that miR‐152 is significantly downregulated in non‐small cell lung cancer (NSCLC) tissues and cell lines. Restoration of miR‐152 significantly reduces proliferation, colony formation, migration and invasion of NSCLC cells. In addition, ADAM metallopeptidase domain 17 (ADAM17) is identified as a target of miR‐152 in NSCLC cells, and miR‐152‐induced suppression of cell proliferation, colony formation, migration and invasion is partially mediated by silencing of ADAM17 expression. Furthermore, ADAM17 inversely correlates with miR‐152 in NSCLC tissues. Collectively, our findings indicate that miR‐152 acts as tumor suppressor in NSCLC partially via targeting ADAM17.