Tumour‐suppressive  microRNA‐224  inhibits cancer cell migration and invasion via targeting oncogenic  TPD52  in prostate cancer | Zendy

Goto Yusuke | Zendy; Nishikawa Rika | Zendy; Kojima Satoko | Zendy; Chiyomaru Takeshi | Zendy; Enokida Hideki | Zendy; Inoguchi Satoru | Zendy; Kinoshita Takashi | Zendy; Fuse Miki | Zendy; Sakamoto Shinichi | Zendy; Nakagawa Masayuki | Zendy; Naya Yukio | Zendy; Ichikawa Tomohiko | Zendy; Seki Naohiko | Zendy

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Tumour‐suppressive microRNA‐224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer

Author(s) -

Goto Yusuke,

Nishikawa Rika,

Kojima Satoko,

Chiyomaru Takeshi,

Enokida Hideki,

Inoguchi Satoru,

Kinoshita Takashi,

Fuse Miki,

Sakamoto Shinichi,

Nakagawa Masayuki,

Naya Yukio,

Ichikawa Tomohiko,

Seki Naohiko

Publication year - 2014

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2014.04.020

Subject(s) - cancer , cancer research , microrna , prostate cancer , biology , cell migration , cancer cell , cell , medicine , gene , genetics

Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA‐224 ( miR‐224 ) is significantly downregulated in PCa tissues. Here, we found that restoration of miR‐224 significantly inhibits PCa cell migration and invasion. Additionally, we found that oncogenic TPD52 is a direct target of miR‐224 regulation. Silencing of the TPD52 gene significantly inhibits cancer cell migration and invasion. Moreover, TPD52 expression is upregulated in cancer tissues and negatively correlates with miR‐224 expression. We conclude that loss of tumour‐suppressive miR‐224 enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic TPD52 .

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