The  Schizosaccharomyces pombe  Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts | Zendy

Oda Yuumi | Zendy; Kimura Makoto | Zendy; Kose Shingo | Zendy; Fasken Milo B. | Zendy; Corbett Anita H. | Zendy; Imamoto Naoko | Zendy

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The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts

Author(s) -

Oda Yuumi,

Kimura Makoto,

Kose Shingo,

Fasken Milo B.,

Corbett Anita H.,

Imamoto Naoko

Publication year - 2014

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2014.04.018

Subject(s) - schizosaccharomyces pombe , hsp70 , schizosaccharomyces , microbiology and biotechnology , heat shock protein , nuclear transport , biology , heat stress , nuclear protein , heat shock , gene , cell nucleus , biochemistry , saccharomyces cerevisiae , nucleus , zoology , transcription factor

Human Hikeshi ( Hs Hikeshi) is a nuclear import carrier for Hsp70s and is required for cell survival after heat shock. The Hikeshi homolog in Schizosaccharomyces pombe ( Sp Hikeshi/Opi10) localizes to the nuclear rim, interacts with the Hsp70 homolog Ssa2, and mediates its nuclear import in a reconstituted mammalian nuclear transport system. However, Sp Hikeshi/Opi10 is not required for heat stress response and survival after heat stress. Instead, Sp Hikeshi/Opi10 is required for the normal expression of stress response genes under optimal conditions and for cell growth during glucose deprivation. Here, the functions of Sp Hikeshi/Opi10 are discussed and compared to the functions of Hs Hikeshi.

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