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The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts
Author(s) -
Oda Yuumi,
Kimura Makoto,
Kose Shingo,
Fasken Milo B.,
Corbett Anita H.,
Imamoto Naoko
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.04.018
Subject(s) - schizosaccharomyces pombe , hsp70 , schizosaccharomyces , microbiology and biotechnology , heat shock protein , nuclear transport , biology , heat stress , nuclear protein , heat shock , gene , cell nucleus , biochemistry , saccharomyces cerevisiae , nucleus , zoology , transcription factor
Human Hikeshi ( Hs Hikeshi) is a nuclear import carrier for Hsp70s and is required for cell survival after heat shock. The Hikeshi homolog in Schizosaccharomyces pombe ( Sp Hikeshi/Opi10) localizes to the nuclear rim, interacts with the Hsp70 homolog Ssa2, and mediates its nuclear import in a reconstituted mammalian nuclear transport system. However, Sp Hikeshi/Opi10 is not required for heat stress response and survival after heat stress. Instead, Sp Hikeshi/Opi10 is required for the normal expression of stress response genes under optimal conditions and for cell growth during glucose deprivation. Here, the functions of Sp Hikeshi/Opi10 are discussed and compared to the functions of Hs Hikeshi.