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Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma
Author(s) -
Wu Dong-ming,
Zhang Peng,
Liu Ru-yan,
Sang Ya-xiong,
Zhou Cong,
Xu Guang-chao,
Yang Jin-liang,
Tong Ai-ping,
Wang Chun-ting
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.03.047
Subject(s) - nucleolin , cancer research , phosphorylation , pi3k/akt/mtor pathway , protein kinase b , metastasis , distribution (mathematics) , colorectal cancer , chemistry , medicine , signal transduction , biology , cancer , microbiology and biotechnology , cytoplasm , mathematical analysis , mathematics , nucleolus
Here, we investigated the molecular mechanism underlying the changes in the distribution of nucleolin. Our study identified PI3K/Akt signaling as an essential pathway regulating the distribution of nucleolin. Furthermore, nucleolin can interact with phospho‐PI3K‐p55, and changes in the distribution of nucleolin were related to its phosphorylation. Subsequently, we analyzed the correlation of VEGF and nucleolin, and found that distribution of nucleolin related to metastatic potential. Finally, blocking cell surface nucleolin influences the process of epithelial–mesenchymal transitions. This indicates that nucleolin may be a novel cancer therapy target and a predictive marker for tumor migration in colorectal carcinoma.