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Tumor suppressor microRNAs: A novel non‐coding alliance against cancer
Author(s) -
Blandino Giovanni,
Fazi Francesco,
Donzelli Sara,
Kedmi Merav,
Sas-Chen Aldema,
Muti Paola,
Strano Sabrina,
Yarden Yosef
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.03.033
Subject(s) - suppressor , alliance , microrna , coding (social sciences) , cancer research , cancer , computational biology , biology , genetics , gene , political science , sociology , social science , law
Tumor initiation and progression are the outcomes of a stepwise accumulation of genetic alterations. Among these, gene amplification and aberrant expression of oncogenic proteins, as well as deletion or inactivation of tumor suppressor genes, represent hallmark steps. Mounting evidence collected over the last few years has identified different populations of non‐coding RNAs as major players in tumor suppression in almost all cancer types. Elucidating the diverse molecular mechanisms underlying the roles of non‐coding RNAs in tumor progression might provide illuminating insights, potentially able to assist improved diagnosis, better staging and effective treatments of human cancers. Here we focus on several groups of tumor suppressor microRNAs, whose downregulation exerts a profound oncologic impact and might be harnessed for the benefit of cancer patients.