Premium
Dynamin related protein 1‐dependent mitochondrial fission regulates oxidative signalling in T cells
Author(s) -
Röth Daniel,
Krammer Peter H.,
Gülow Karsten
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.03.029
Subject(s) - mitochondrial fission , fission , oxidative phosphorylation , microbiology and biotechnology , dynamin , signalling , mitochondrion , chemistry , dnm1l , biology , biochemistry , physics , cell , endocytosis , quantum mechanics , neutron
In T cells mitochondria‐derived reactive oxygen species (ROS) are indispensible for activation of the transcription factor NF‐κB, expression of cytokines and the CD95 ligand (CD95L/FasL). Here we show that activation‐induced ROS generation is dependent on mitochondrial fission. Inhibition of dynamin related protein 1 (Drp1) results in reduced ROS levels and transcriptional activity of NF‐κB leading to diminished proliferation and CD95L‐dependent activation‐induced cell death (AICD). Upon stimulation Drp1 is S‐nitrosylated, which is required for oxidative signalling, AICD and cytokine production. In conclusion, we describe a novel signalling pathway that links TCR‐induced nitric oxide release to mitochondrial fission and oxidative signalling.