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AROS has a context‐dependent effect on SIRT1
Author(s) -
Kokkola Tarja,
Suuronen Tiina,
Molnár Ferdinand,
Määttä Juha,
Salminen Antero,
Jarho Elina M.,
Lahtela-Kakkonen Maija
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.03.020
Subject(s) - regulator , context (archaeology) , endogeny , chemistry , in vitro , biochemistry , microbiology and biotechnology , biology , gene , paleontology
The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging‐associated diseases. Active regulator of SIRT1 (AROS) is a small endogenous protein which was originally reported to activate SIRT1 through a direct interaction in cancer cells. We show that the interaction between the two proteins is weak and does not alter the activity of SIRT1 in non‐cancerous human cells. The results of different in vitro SIRT1 activity assays disclosed AROS as an inhibitor of SIRT1. The functional relationship between AROS and SIRT1 proved to be dependent on the biological context and experimental setting.