Premium
Relationship between gut microbiota and development of T cell associated disease
Author(s) -
Kosiewicz Michele M.,
Dryden Gerald W.,
Chhabra Anita,
Alard Pascale
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.03.019
Subject(s) - immune system , gut flora , immunology , biology , commensalism , disease , gut–brain axis , autoimmune disease , immunity , medicine , antibody , bacteria , genetics , pathology
The interplay between the immune response and the gut microbiota is complex. Although it is well‐established that the gut microbiota is essential for the proper development of the immune system, recent evidence indicates that the cells of the immune system also influence the composition of the gut microbiota. This interaction can have important consequences for the development of inflammatory diseases, including autoimmune diseases and allergy, and the specific mechanisms by which the gut commensals drive the development of different types of immune responses are beginning to be understood. Furthermore, sex hormones are now thought to play a novel role in this complex relationship, and collaborate with both the gut microbiota and immune system to influence the development of autoimmune disease. In this review, we will focus on recent studies that have transformed our understanding of the importance of the gut microbiota in inflammatory responses.