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Keep‐ING balance: Tumor suppression by epigenetic regulation
Author(s) -
Tallen Gesche,
Riabowol Karl
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.03.011
Subject(s) - epigenetics , chromatin , histone , effector , biology , chromatin remodeling , regulation of gene expression , computational biology , microbiology and biotechnology , genetics , gene
The ING (inhibitor of growth) proteins (ING1–ING5) have emerged as a versatile family of growth regulators, phospholipid effectors, histone mark sensors and core components of HDAC1/2 – and several HAT chromatin‐modifying complexes. This review will describe the characteristic pathways by which ING family proteins differentially affect the Hallmarks of Cancer and highlight the various epigenetic mechanisms by which they regulate gene expression. Finally, we will discuss their potentials as biomarkers and therapeutic targets in epigenetic treatment strategies.