Type 2 ryanodine receptors are highly sensitive to alcohol | Zendy

Ye Yanping | Zendy; Jian Kuihuan | Zendy; Jaggar Jonathan H. | Zendy; Bukiya An. | Zendy; Dopico Alex M. | Zendy

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Type 2 ryanodine receptors are highly sensitive to alcohol

Author(s) -

Ye Yanping,

Jian Kuihuan,

Jaggar Jonathan H.,

Bukiya An.,

Dopico Alex M.

Publication year - 2014

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2014.03.005

Subject(s) - ryanodine receptor , ryanodine receptor 2 , ethanol , chemistry , receptor , biophysics , alcohol , vasodilation , cerebral arteries , vascular smooth muscle , medicine , microbiology and biotechnology , endocrinology , biochemistry , biology , smooth muscle

Exposure to ethanol levels reached in circulation during alcohol intoxication ( > 10 mM) constricts cerebral arteries in rats and humans. Remarkably, targets and mechanisms underlying this action remain largely unidentified. Artery diameter is regulated by myocyte Ca 2+ sparks, a vasodilatory signal contributed to by type 2 ryanodine receptors (RyR2). Using laser confocal microscopy in rat cerebral arteries and bilayer electrophysiology we unveil that ethanol inhibits both Ca 2+ spark and RyR2 activity with IC 50 < 20 mM, placing RyR2 among the ion channels that are most sensitive to ethanol. Alcohol directly targets RyR2 and its lipid microenvironment, leading to stabilization of RyR2 closed states.

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