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MiR‐129‐5p is down‐regulated and involved in the growth, apoptosis and migration of medullary thyroid carcinoma cells through targeting RET
Author(s) -
Duan Lijun,
Hao Xiaofang,
Liu Zhiyong,
Zhang Yang,
Zhang Guangling
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.03.002
Subject(s) - cancer research , microrna , thyroid carcinoma , ectopic expression , carcinogenesis , cell growth , transfection , oncogene , apoptosis , suppressor , medullary cavity , protein kinase b , biology , microbiology and biotechnology , signal transduction , thyroid , cell culture , medicine , cell cycle , endocrinology , cancer , gene , genetics
Dysregulation of the REarranged during Transfection proto‐oncogene (RET) pathway and microRNA (miRNAs) are crucial for the development of medullary thyroid carcinomas (MTC). Here we demonstrate that miR‐129‐5p is down‐regulated in MTC tissues and cell lines and inhibits RET expression by directly binding its 3′ untranslated regions. Ectopic expression of miR‐129‐5p significantly decreases cell growth, induces apoptosis and suppresses migration ability in MTC cells through decreasing the phosphorylated AKT, thus functioning as a tumor suppressor. These findings give new clues for understanding MTC carcinogenesis and may help in developing a therapeutic approach for the treatment of RET‐activated MTC.