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A proneural gene controls C. elegans neuroblast asymmetric division and migration
Author(s) -
Zhu Zhiwen,
Liu Jianhong,
Yi Peishan,
Tian Dong,
Chai Yongping,
Li Wei,
Ou Guangshuo
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.02.036
Subject(s) - neuroblast , biology , proneural genes , cell division , microbiology and biotechnology , numb , asymmetric cell division , transcription factor , gene , genetics , caenorhabditis elegans , cell , neurogenesis
Proneural genes control the generation of neuroblasts from the neuroepithelium, but their functions in neuroblast asymmetric division and migration remain elusive. Here, we identified C aenorhabditis elegans mutants of a proneural transcription factor (TF) lin‐32 , in which Q neuroblasts are produced. We showed that LIN‐32 functions in parallel with a storkhead TF, HAM‐1, to regulate Q neuroblast asymmetric division, and that Q neuroblast migration is inhibited in lin‐32 alleles. Consistently, lin‐32 is expressed throughout Q neuroblast lineage, suggesting that LIN‐32 may promote different target gene expression. Our studies thus uncovered previously unknown functions of a proneural gene in neuroblast development.