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Membrane‐bound delta‐like 1 homolog (Dlk1) promotes while soluble Dlk1 inhibits myogenesis in C2C12 cells
Author(s) -
Shin Sangsu,
Suh Yeunsu,
Zerby Henry N.,
Lee Kichoon
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.02.027
Subject(s) - myogenesis , c2c12 , gene isoform , phenotype , microbiology and biotechnology , myocyte , chemistry , biology , gene , biochemistry
Delta‐like 1 homolog ( Dlk1 ) is important in myogenesis. However, the roles of different Dlk1 isoforms have not been investigated. In C2C12 cell lines producing different Dlk1 isoforms, membrane‐bound Dlk1 promoted the hypertrophic phenotype and a higher fusion rate, whereas soluble Dlk1 inhibited myotube formation. Inversed expression patterns of genes related to myogenic differentiation further support these phenotypic changes. In addition, temporal expression and balance between the Dlk1 isoforms have a regulatory role in myogenesis in vivo . Collectively, Dlk1 isoforms have distinctive effects on myogenesis, and its regulation during myogenesis is critical for normal muscle development.