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Transcriptional control of RfaH on polysialic and colanic acid synthesis by Escherichia coli K92
Author(s) -
Navasa Nicolás,
Rodríguez-Aparicio Leandro B.,
Ferrero Miguel Ángel,
Monteagudo-Mera Andrea,
Martínez-Blanco Honorina
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.01.047
Subject(s) - polysialic acid , operon , escherichia coli , virulence , biology , transcriptional regulation , transcription (linguistics) , microbiology and biotechnology , transcription factor , cell , biochemistry , gene , cell adhesion , neural cell adhesion molecule , linguistics , philosophy
The transcriptional antiterminator RfaH promotes transcription of long operons encoding surface cell components important for the virulence of Escherichia coli pathogens. In this paper, we show that RfaH enhanced kps expression for the synthesis of group 2 polysialic acid capsule in E. coli K92. In addition, we demonstrate for the first time that RfaH promotes cps expression for the synthesis of colanic acid, a cell wall component with apparently no role on pathogenicity. Finally, we show a novel RfaH requirement for growth at low temperatures.