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End‐binding protein 1 (EB1) up‐regulation is an early event in colorectal carcinogenesis
Author(s) -
Stypula-Cyrus Yolanda,
Mutyal Nikhil N.,
Dela Cruz Mart,
Kunte Dhananjay P.,
Radosevich Andrew J.,
Wali Ramesh,
Roy Hemant K.,
Backman Vadim
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.01.046
Subject(s) - carcinogenesis , colorectal cancer , event (particle physics) , cancer research , medicine , biology , cancer , physics , quantum mechanics
End‐binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression is unknown. Therefore, we analyzed EB1/APC expression at the earliest stages of colorectal carcinogenesis and in the uninvolved mucosa (“field effect”) of human and animal tissue. We also performed siRNA‐knockdown in colon cancer cell lines. EB1 is up‐regulated in early and field carcinogenesis in the colon, and the cellular/nano‐architectural effect of EB1 knockdown depended on the genetic context. Thus, dysregulation of EB1 is an important early event in colon carcinogenesis.