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miR‐625 down‐regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2
Author(s) -
Wang Zhiqiang,
Qiao Qiao,
Chen Min,
Li Xianhua,
Wang Zhenjun,
Liu Chuanxin,
Xie Zongtao
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.01.035
Subject(s) - western blot , sox2 , cancer research , esophageal cancer , luciferase , microrna , cell growth , biology , mechanism (biology) , cancer , microbiology and biotechnology , chemistry , cell culture , gene , transfection , transcription factor , genetics , philosophy , epistemology
miR‐625 has been reported to exhibit abnormal expression in esophageal cancer (EC), but the mechanism and functions of miR‐625 in esophageal cancer remain unclear. miR‐625 down‐regulation and Sox2 up‐regulation were validated by qRT‐PCR in 158 EC samples. Low expression of miR‐625 promotes cell proliferation and invasion, while high expression of miR‐625 has the opposite effect. Sox2, a target gene of miR‐625, was examined by luciferase assay and western blot. Our data suggest that miR‐625 may regulate the biological processes of EC via controlling Sox2 expression.