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Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF‐1
Author(s) -
Cho Hyun Kook,
Kim So Young,
Seong Je Kyung,
Cheong JaeHun
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2014.01.017
Subject(s) - hbx , immune system , chemokine , hepatitis b virus , biology , cytokine , stromal cell , chemokine receptor , virus , immunology , cancer research
Hepatitis B virus X protein is a major factor in the HBV‐induced disease developments. Stromal cell‐derived factor‐1 is a small cytokine that is strongly chemotactic for lymphocytes. We explored the role of HBx on recruitment of HBV‐induced virus‐nonspecific immune cells into liver. Immune cell recruitment and SDF‐1 expression level significantly increased in livers of HBx‐transgenic mice and X‐box binding protein‐1 significantly increased SDF‐1 gene expression. Finally, we confirmed that immune cell recruitment into liver tissues of HBx‐TG mice was diminished by a chemokine receptor antagonist. Therefore, HBx increases ER stress‐dependent SDF‐1 expression and induces HBV‐induced immune cell recruitment into liver.