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MicroRNA‐106a targets TIMP2 to regulate invasion and metastasis of gastric cancer
Author(s) -
Zhu Meng,
Zhang Ning,
He Shuixiang,
Lui Yuanyuan,
Lu Guifang,
Zhao Lin
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.12.028
Subject(s) - metastasis , microrna , gene knockdown , cancer , cancer research , cancer metastasis , biology , medicine , apoptosis , gene , genetics
Emerging evidence has shown that microRNA plays an important role in tumor development and progression. Here, we report that miR‐106a is frequently up‐regulated in gastric cancer tissues and positively correlates with metastasis. Restrained expression of miR‐106a in gastric cancer cells significantly reduces their capacity of proliferation, migration and invasion. In tissue sections, the positive signal of miR‐106a localized in metastasis‐associated regions confirmed this result. Moreover, we show that TIMP2 is a direct downstream target for miR‐106a and knockdown of TIMP2 strengthens the beneficial effects of miR‐106a. Our study adds miR‐106a to the complex mechanisms of tumor metastasis.