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MiR‐98 is involved in rat embryo implantation by targeting Bcl‐xl
Author(s) -
Xia Hong-Fei,
Jin Xiao-Hua,
Cao Zong-Fu,
Shi Tian,
Ma Xu
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.12.026
Subject(s) - embryo , microrna , bcl xl , three prime untranslated region , apoptosis , untranslated region , biology , andrology , microbiology and biotechnology , messenger rna , chemistry , medicine , programmed cell death , gene , genetics
In a previous study, via microRNA microarray analysis we found that miR‐98 is differentially expressed in rat uteri during the peri‐implantation period (unpublished data). However, the role of miR‐98 in rat embryo implantation remains elusive. Here, we found that the level of miR‐98 is lower on day 5 and 6 of gestation (g.d. 5–6) than that on g.d. 3–4 and g.d. 7–8 in rat. MiR‐98 expression is significantly decreased by delayed implantation. Down‐regulation of miR‐98 promotes ESC proliferation and inhibits apoptosis. Up‐regulation of miR‐98 displays opposite effects. Further investigation revealed that miR‐98 can bind to the 3′‐untranslated region (3′‐UTR) of B‐cell lymphoma‐extra large ( Bcl‐xl ) to inhibit Bcl‐xl translation. Collectively, down‐regulation of miR‐98 in rat uterus during the receptive phase is linked to the increase of cell proliferation via targeting Bcl‐xl .