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Mutations in the D‐channel of cytochrome c oxidase causes leakage of the proton pump
Author(s) -
Siegbahn Per E.M.,
Blomberg Margareta R.A.
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.12.020
Subject(s) - cytochrome c oxidase , proton , chemistry , leakage (economics) , biophysics , point mutation , cytochrome , biochemistry , enzyme , physics , mutation , biology , gene , quantum mechanics , economics , macroeconomics
It has experimentally been found that certain mutations close to the entry point of the proton transfer channel in cytochrome c oxidase stop proton translocation but not the oxygen reduction chemistry. This effect is termed uncoupling. Since the mutations are 20 Å away from the catalytic center, this is very surprising. A new explanation for this phenomenon is suggested here, involving a local effect at the entry point of the proton channel, rather than the long range effects suggested earlier.