2,3‐Dihydroxy‐quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase | Zendy

Zeifman Alexey A. | Zendy; Novikov Fedor N. | Zendy; Stroylov Victor S. | Zendy; Stroganov Oleg V. | Zendy; Chilov Ghermes G. | Zendy; Skoblov Alexander Y. | Zendy; Miroshnikov Anatoly I. | Zendy; Skoblov Yuri S. | Zendy

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2,3‐Dihydroxy‐quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase

Author(s) -

Zeifman Alexey A.,

Novikov Fedor N.,

Stroylov Victor S.,

Stroganov Oleg V.,

Chilov Ghermes G.,

Skoblov Alexander Y.,

Miroshnikov Anatoly I.,

Skoblov Yuri S.

Publication year - 2014

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2013.12.017

Subject(s) - quinoxaline , thymidine kinase , herpes simplex virus , chemistry , kinase , phosphorylation , enzyme , virology , hydrolysis , thymidine , ic50 , microbiology and biotechnology , virus , biochemistry , biology , in vitro , organic chemistry

2,3‐Dihydroxy‐quinoxaline, a small molecule that promotes ATPase catalytic activity of Herpes Simplex Virus thymidine kinase (HSV‐TK), was identified by virtual screening. This compound competitively inhibited HSV‐TK catalyzed phosphorylation of acyclovir with K i = 250 μM (95% CI: 106–405 μM) and dose‐dependently increased the rate of the ATP hydrolysis with K M = 112 μM (95% CI: 28–195 μM). The kinetic scheme consistent with this experimental data is proposed.

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