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Upregulation of MicroRNA‐107 induces proliferation in human gastric cancer cells by targeting the transcription factor FOXO1
Author(s) -
Li Fan,
Liu Baohua,
Gao Yu,
Liu Yuliang,
Xu Yu,
Tong Weidong,
Zhang Anping
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.12.009
Subject(s) - microrna , downregulation and upregulation , cancer , cell growth , cancer cell , transcription factor , cancer research , biology , regulator , apoptosis , foxo1 , microbiology and biotechnology , gene , genetics
MicroRNA‐107 (miR‐107) has been demonstrated to regulate proliferation and apoptosis in many types of cancers. Nevertheless, its biological function in gastric cancer remains largely unexplored. Here, we found that the expression level of miR‐107 was increased in gastric cancer in comparison with the adjacent normal tissues. The enforced expression of miR‐107 was able to promote cell proliferation in NCI‐N87 and AGS cells, while miR‐107 antisense oligonucleotides (antisense miR‐107) blocked cell proliferation. At the molecular level, our results further revealed that expression of FOXO1 was negatively regulated by miR‐107. Therefore, the data reported here demonstrate that miR‐107 is an important regulator in gastric cancer, which will contribute to a better understanding of the important mis‐regulated miRNAs in gastric cancer.