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Cell and tissue‐autonomous development of the circadian clock in mouse embryos
Author(s) -
Inada Yutaka,
Uchida Hitoshi,
Umemura Yasuhiro,
Nakamura Wataru,
Sakai Takayoshi,
Koike Nobuya,
Yagita Kazuhiro
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.12.007
Subject(s) - circadian rhythm , suprachiasmatic nucleus , biology , circadian clock , light effects on circadian rhythm , microbiology and biotechnology , period (music) , reprogramming , bacterial circadian rhythms , embryonic stem cell , neuroscience , endocrinology , medicine , cell , genetics , physics , gene , acoustics
The emergence of the circadian rhythm is a dramatic and physiologically essential event for mammals to adapt to daily environmental cycles. It has been demonstrated that circadian rhythms develop during the embryonic stage even when the maternal central pacemaker suprachiasmatic nucleus has been disrupted. However, the mechanisms controlling development of the circadian clock are not yet fully understood. Here, we show that the circadian molecular oscillation in primary dispersed embryonic cells and explanted salivary glands obtained from mPER2 Luc mice embryos developed cell‐ or tissue‐autonomously even in tissue culture conditions. Moreover, the circadian clock in the primary mPER2 Lu c fibroblasts could be reprogrammed by the expression of the reprogramming factors. These findings suggest that mammalian circadian clock development may interact with cellular differentiation mechanisms.