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An oxalyl‐CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae
Author(s) -
Foster Justin,
Nakata Paul A.
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.11.026
Subject(s) - saccharomyces cerevisiae , oxalate , oxalic acid , enzyme , biochemistry , chemistry , endogeny , metabolism , yeast , organic chemistry
Although oxalic acid is common in nature our understanding of the mechanism(s) regulating its turnover remains incomplete. In this study we identify Saccharomyces cerevisiae acyl‐activating enzyme 3 (ScAAE3) as an enzyme capable of catalyzing the conversion of oxalate to oxalyl‐CoA. Based on our findings we propose that ScAAE3 catalyzes the first step in a novel pathway of oxalate degradation to protect the cell against the harmful effects of oxalate derived from an endogenous process or an environmental source.