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miR‐181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells
Author(s) -
Yang Lei,
Wang Yan-Li,
Liu Shang,
Zhang Pei-Pei,
Chen Zheng,
Liu Min,
Tang Hua
Publication year - 2014
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.11.019
Subject(s) - adenylyl cyclase , apoptosis , cell growth , microrna , biology , cancer research , gene , cell , microbiology and biotechnology , signal transduction , genetics
MicroRNAs are a class of small, endogenous, non‐coding RNAs that function as post‐transcriptional regulators. In this study, we found that miR‐181b promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells. And we validated a new miR‐181b target gene, adenylyl cyclase 9 (AC9). miR‐181b restricted cAMP production by post‐transcriptionally downregulating AC9 expression. Phenotypic experiments indicated that miR‐181b and AC9 exerted opposite effects on cell proliferation and apoptosis.