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Solution NMR studies of the plant peptide hormone CEP inform function
Author(s) -
Bobay Benjamin G.,
DiGennaro Peter,
Scholl Elizabeth,
Imin Nijat,
Djordjevic Michael A.,
Mck Bird David
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.10.033
Subject(s) - peptide , nematode , root knot nematode , cyclic peptide , molecular dynamics , plant hormone , biology , biochemistry , chemistry , biophysics , stereochemistry , microbiology and biotechnology , ecology , computational chemistry , gene
The C‐terminally Encoded Peptide (CEP) family of regulatory peptides controls root development in vascular plants. Here, we present the first NMR structures of CEP. We show that root‐knot nematode (RKN: Meloidogyne spp.) also encodes CEP, presumably to mimic plant CEP as part of their stereotypic, parasitic interaction with vascular plants. Molecular dynamics simulations of plant‐ and nematode‐encoded CEP displaying known posttranslational modifications (PTM) provided insight into the structural effects of PTM and the conformational plasticity and rigidity of CEP. Potential mechanisms of action are discussed with respect to the structure and sampling of conformational space.