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Hsa‐miR‐125b suppresses bladder cancer development by down‐regulating oncogene SIRT7 and oncogenic long non‐coding RNA MALAT1
Author(s) -
Han Yonghua,
Liu Yuchen,
Zhang Hu,
Wang Tiantian,
Diao Ruiying,
Jiang Zhimao,
Gui Yaoting,
Cai Zhiming
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.10.023
Subject(s) - malat1 , oncogene , gene silencing , microrna , bladder cancer , cancer research , long non coding rna , rna , cancer , chemistry , biology , gene , genetics , cell cycle , biochemistry
MicroRNAs mainly inhibit coding genes and long non‐coding RNA expression. Here, we report that hsa‐miR‐125b and oncogene SIRT7/oncogenic long non‐coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa‐miR‐125b mimic down‐regulated, whereas hsa‐miR‐125b inhibitor up‐regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa‐miR‐125b and SIRT7/MALAT1. Up‐regulation of hsa‐miR‐125b or down‐regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up‐regulation of hsa‐miR‐125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa‐miR‐125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1.