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PPARalpha regulates the production of serum Vanin‐1 by liver
Author(s) -
Rommelaere Samuel,
Millet Virginie,
Gensollen Thomas,
Bourges Christophe,
Eeckhoute Jérôme,
Hennuyer Nathalie,
Baugé Eric,
Chasson Lionel,
Cacciatore Ivana,
Staels Bart,
Pitari Giuseppina,
Galland Franck,
Naquet Philippe
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.09.046
Subject(s) - secretion , limiting , chemistry , adaptation (eye) , cysteine , homeostasis , medicine , endocrinology , microbiology and biotechnology , biology , biochemistry , enzyme , mechanical engineering , neuroscience , engineering
The membrane‐bound Vanin‐1 pantetheinase regulates tissue adaptation to stress. We investigated Vnn1 expression and its regulation in liver. Vnn1 is expressed by centrolobular hepatocytes. Using novel tools, we identify a soluble form of Vnn1 in mouse and human serum and show the contribution of a cysteine to its catalytic activity. We show that liver contributes to Vanin‐1 secretion in serum and that PPARalpha is a limiting factor in serum Vnn1 production. Functional PPRE sites are identified in the Vnn1 promoter. These results indicate that serum Vnn1 might be a reliable reporter of PPARalpha activity in liver.