PPARalpha regulates the production of serum Vanin‐1 by liver | Zendy

Rommelaere Samuel | Zendy; Millet Virginie | Zendy; Gensollen Thomas | Zendy; Bourges Christophe | Zendy; Eeckhoute Jérôme | Zendy; Hennuyer Nathalie | Zendy; Baugé Eric | Zendy; Chasson Lionel | Zendy; Cacciatore Ivana | Zendy; Staels Bart | Zendy; Pitari Giuseppina | Zendy; Galland Franck | Zendy; Naquet Philippe | Zendy

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PPARalpha regulates the production of serum Vanin‐1 by liver

Author(s) -

Rommelaere Samuel,

Millet Virginie,

Gensollen Thomas,

Bourges Christophe,

Eeckhoute Jérôme,

Hennuyer Nathalie,

Baugé Eric,

Chasson Lionel,

Cacciatore Ivana,

Staels Bart,

Pitari Giuseppina,

Galland Franck,

Naquet Philippe

Publication year - 2013

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2013.09.046

Subject(s) - secretion , limiting , adaptation (eye) , chemistry , homeostasis , cysteine , microbiology and biotechnology , medicine , endocrinology , biology , biochemistry , enzyme , mechanical engineering , neuroscience , engineering

The membrane‐bound Vanin‐1 pantetheinase regulates tissue adaptation to stress. We investigated Vnn1 expression and its regulation in liver. Vnn1 is expressed by centrolobular hepatocytes. Using novel tools, we identify a soluble form of Vnn1 in mouse and human serum and show the contribution of a cysteine to its catalytic activity. We show that liver contributes to Vanin‐1 secretion in serum and that PPARalpha is a limiting factor in serum Vnn1 production. Functional PPRE sites are identified in the Vnn1 promoter. These results indicate that serum Vnn1 might be a reliable reporter of PPARalpha activity in liver.

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