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miR‐338‐3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a
Author(s) -
Chen Xin,
Pan Min,
Han Lulu,
Lu Hongting,
Hao Xiwei,
Dong Qian
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.09.044
Subject(s) - pten , cell growth , microrna , protein kinase b , cancer research , gene knockdown , cell migration , neuroblastoma , pi3k/akt/mtor pathway , microbiology and biotechnology , biology , metastasis , cell cycle , cell cycle checkpoint , cell , signal transduction , cancer , apoptosis , cell culture , gene , genetics
MicroRNAs (miRNA) can regulate cancer cell proliferation and metastasis. Here, we show that miR‐338‐3p is down‐regulated in metastatic tumor tissues compared to primary tumors, and that that miR‐338‐3p can inhibit cell proliferation by inducing cell cycle arrest, as well as restrain cell migration and invasion. PREX2a is confirmed as a direct target of miR‐338‐3p. Knockdown of PREX2a inhibits cell proliferation, migration and invasion through the PTEN/Akt pathway. miR‐338‐3p‐dependent inhibition of proliferation and invasion can be rescued by PREXa. Overall, this study demonstrates that miR‐338‐3p affects the PTEN/Akt pathway by down‐regulating PREX2a. This newly identified function of miR‐338‐3p provides novel insights into neuroblastoma and may foster therapeutic applications.