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Interplay between polymerase II‐ and polymerase III‐assisted expression of overlapping genes
Author(s) -
Lukoszek Radoslaw,
Mueller-Roeber Bernd,
Ignatova Zoya
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.09.033
Subject(s) - rna polymerase iii , rna polymerase ii , gene , transcription factor ii d , biology , rna polymerase ii holoenzyme , transcription (linguistics) , genetics , rna polymerase , polymerase , microbiology and biotechnology , gene expression , dna polymerase , rna , promoter , linguistics , philosophy
Up to 15% of the genes in different genomes overlap. This architecture, although beneficial for the genome size, represents an obstacle for simultaneous transcription of both genes. Here we analyze the interference between RNA‐polymerase II (Pol II) and RNA‐polymerase III (Pol III) when transcribing their target genes encoded on opposing strands within the same DNA fragment in Arabidopsis thaliana . The expression of a Pol II‐dependent protein‐coding gene negatively correlated with the transcription of a Pol III‐dependent, tRNA‐coding gene set. We suggest that the architecture of the overlapping genes introduces an additional layer of control of gene expression.