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Targeting PKCε by miR‐143 regulates cell apoptosis in lung cancer
Author(s) -
Zhang Ni,
Su Yunshu,
Xu Lijun
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.09.018
Subject(s) - lung cancer , apoptosis , cancer research , protein kinase c , cell growth , pathogenesis , cancer , cell , biology , microrna , medicine , kinase , microbiology and biotechnology , oncology , immunology , gene , genetics
Non‐small cell lung cancer (NSCLC) is one of the most common causes for lung cancer and cancer‐related death. The imbalance between cell proliferation and apoptosis was suggested to play an important role in cancer pathogenesis and PKCε is one of the widely recognized targets. Here, we demonstrate that miR‐143 is aberrantly downregulated in NSCLC tissue and negatively correlates with expression of PKCε. We show that miR‐143 specifically targets the 3′‐UTR of PKCε and regulates its expression. Treatment with miR‐143 inhibitor mimics cell proliferation and apoptosis imbalance in NSCLC, while inhibition of PKCε can reverse it. Our findings suggest that targeting PKCε overexpression in NSCLC should be beneficial for lung cancer therapy.