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Chicken IL‐6 is a heat‐shock gene
Author(s) -
Prakasam Ramachandran,
Fujimoto Mitsuaki,
Takii Ryosuke,
Hayashida Naoki,
Takaki Eiichi,
Tan Ke,
Wu Fangxu,
Inouye Sachiye,
Nakai Akira
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.09.012
Subject(s) - heat shock , hsf1 , heat shock protein , biology , gene , cytokine , microbiology and biotechnology , shock (circulatory) , immunology , hsp70 , genetics , medicine
The febrile response is elicited by pyrogenic cytokines including IL‐6 in response to microorganism infections and diseases in vertebrates. Mammalian HSF1, which senses elevations in temperature, negatively regulates the response by suppressing pyrogenic cytokine expression. We here showed that HSF3, an avian ortholog of mammalian HSF1, directly binds to and activates IL‐6 during heat shock in chicken cells. Other components of the febrile response mechanism, such as IL‐1β and ATF3, were also differently regulated in mammalian and chicken cells. These results suggest that the febrile response is exacerbated by a feed‐forward circuit composed of the HSF3‐IL‐6 pathway in birds.