Premium
Coronary heart disease alters intercellular communication by modifying microparticle‐mediated microRNA transport
Author(s) -
Finn Nnenna A.,
Eapen Danny,
Manocha Pankaj,
Al Kassem Hatem,
Lassegue Bernard,
Ghasemzadeh Nima,
Quyyumi Arshed,
Searles Charles D.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.08.034
Subject(s) - microrna , intracellular , coronary heart disease , microparticle , biology , disease , microbiology and biotechnology , medicine , genetics , gene , astrobiology
Coronary heart disease (CHD) is characterized by abnormal intercellular communication and circulating microRNAs (miRNAs) are likely involved in this process. Here, we show that CHD was associated with changes in the transport of circulating miRNA, particularly decreased miRNA enrichment in microparticles (MPs). Additionally, MPs from CHD patients were less efficient at transferring miRNA to cultured HUVECs, which correlated with their diminished capacity to bind developmental endothelial locus‐1 (Del‐1). In summary, CHD was associated with distinct changes in circulating miRNA transport and these changes may contribute to the abnormal intercellular communication that underlies CHD initiation and progression.