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Protein interactions between surface annexin A2 and S100A10 mediate adhesion of breast cancer cells to microvascular endothelial cells
Author(s) -
Myrvang Helene K.,
Guo Xiaoxia,
Li Chan,
Dekker Lodewijk V.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.08.012
Subject(s) - annexin a2 , microbiology and biotechnology , annexin , cell , cancer cell , chemistry , cell adhesion , endothelial stem cell , biology , cancer , biochemistry , in vitro , genetics
Annexin A2 (AnxA2) and S100A10 are known to form a molecular complex. Using fluorescence‐based binding assays, we show that both proteins are localised on the cell surface, in a molecular form that allows mutual interaction. We hypothesized that binding between these proteins could facilitate cell–cell interactions. For cells that express surface S100A10 and surface annexin A2, cell–cell interactions can be blocked by competing with the interaction between these proteins. Thus an annexin A2‐S100A10 molecular bridge participates in cell–cell interactions, revealing a hitherto unexplored function of this protein interaction.