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MicroRNA‐106a induces multidrug resistance in gastric cancer by targeting RUNX3
Author(s) -
Zhang Yi,
Lu Qiping,
Cai Xun
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.06.058
Subject(s) - efflux , multiple drug resistance , microrna , apoptosis , cancer , drug resistance , function (biology) , cancer research , pharmacology , chemistry , biology , gene , microbiology and biotechnology , biochemistry , genetics
Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for gastric cancer (GC). miR‐106a, which is highly expressed in GC, influences a variety of aspects of GC. However, the function of miR‐106a in MDR of GC still remains unclear. In the present study, we found that miR‐106a is elevated in MDR cell lines. miR‐106a promotes chemo‐resistance of GC cells, accelerates ADR efflux, and suppresses drug‐induced apoptosis. Finally, we show that runt‐related trans factor 3 (RUNX3) is the functional target of miR‐106a. Collectively, these findings demonstrate that miR‐106a may promote MDR in GC cells by targeting RUNX3.