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Sprouty2 but not Sprouty4 is a potent inhibitor of cell proliferation and migration of osteosarcoma cells
Author(s) -
Rathmanner Nadine,
Haigl Barbara,
Vanas Vanita,
Doriguzzi Angelina,
Gsur Andrea,
Sutterlüty-Fall Hedwig
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.06.040
Subject(s) - osteosarcoma , cell growth , cell migration , microbiology and biotechnology , cancer research , protein kinase a , carcinogenesis , tyrosine kinase , biology , suppressor , receptor tyrosine kinase , kinase , cell , signal transduction , chemistry , cancer , biochemistry , genetics
As negative regulators of receptor tyrosine kinase‐mediated signalling, Sprouty proteins fulfil important roles during carcinogenesis. In this report, we demonstrate that Sprouty2 protein expression inhibits cell proliferation and migration in osteosarcoma‐derived cells. Although earlier reports describe a tumour‐promoting function, these results indicate that Sprouty proteins also have the potential to function as tumour suppressors in sarcoma. In contrast to Sprouty2, Sprouty4 expression failed to interfere with proliferation and migration of the osteosarcoma‐derived cells, possibly due to a less pronounced interference with mitogen‐activated protein kinase activity. Sequences within the NH 2 ‐terminus are responsible for the specific inhibitory function of Sprouty2 protein.