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Cohesin: Functions beyond sister chromatid cohesion
Author(s) -
Mehta Gunjan D.,
Kumar Ravinder,
Srivastava Sanjeeva,
Ghosh Santanu Kumar
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.06.035
Subject(s) - cohesin , establishment of sister chromatid cohesion , sister chromatids , separase , chromatid , chromosome segregation , kinetochore , genetics , biology , anaphase , microbiology and biotechnology , meiosis , mitosis , condensin , chromosome , gene
Faithful segregation of chromosomes during mitosis and meiosis is the cornerstone process of life. Cohesin, a multi‐protein complex conserved from yeast to human, plays a crucial role in this process by keeping the sister chromatids together from S‐phase to anaphase onset during mitosis and meiosis. Technological advancements have discovered myriad functions of cohesin beyond its role in sister chromatid cohesion (SCC), such as transcription regulation, DNA repair, chromosome condensation, homolog pairing, monoorientation of sister kinetochore, etc. Here, we have focused on such functions of cohesin that are either independent of or dependent on its canonical role of sister chromatid cohesion. At the end, human diseases associated with malfunctioning of cohesin, albeit with mostly unperturbed sister chromatid cohesion, have been discussed.