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Elevated citrate levels in non‐alcoholic fatty liver disease: The potential of citrate to promote radical production
Author(s) -
van de Wier Bregje,
Balk Jiska M.,
Haenen Guido R.M.M.,
Giamouridis Dimosthenis,
Bakker Jaap A.,
Bast Bertine C.,
den Hartog Gertjan J.M.,
Koek Ger H.,
Bast Aalt
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.06.019
Subject(s) - fatty liver , chemistry , alcoholic liver disease , atp citrate lyase , medicine , biochemistry , endocrinology , citrate synthase , disease , cirrhosis , enzyme
Plasma citrate levels were found to be elevated in non‐alcoholic fatty liver disease (NAFLD) patients. Cellular experiments indicated that increased citrate levels might originate from an excess of fatty acids. The impact of elevated citrate levels on oxidative stress was examined. It was found that citrate stimulated hydrogen peroxide induced intracellular oxidative stress in HepG2 cells. This was related to the promotion of iron mediated hydroxyl radical formation from hydrogen peroxide by citrate. The stimulating effect of citrate on the reactivity of iron promotes oxidative stress, a crucial process in the progression of NAFLD.