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Circadian gene Clock contributes to cell proliferation and migration of glioma and is directly regulated by tumor‐suppressive miR‐124
Author(s) -
Li Aihua,
Lin Xihua,
Tan Xiaochao,
Yin Bin,
Han Wei,
Zhao Jizong,
Yuan Jiangang,
Qiang Boqin,
Peng Xiaozhong
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.06.018
Subject(s) - glioma , carcinogenesis , clock , gene silencing , circadian clock , microrna , cancer research , circadian rhythm , biology , cell growth , suppressor , microbiology and biotechnology , gene , neuroscience , genetics
Although the roles of circadian Clock genes and microRNAs in tumorigenesis have been profoundly studied, mechanisms of cross‐talk between them in regulation of gliomagenesis are poorly understood. Here we show that the expression level of CLOCK is significantly increased in high‐grade human glioma tissues and glioblastoma cell lines. In contrast miR‐124 is attenuated in similar samples. Further studies show that Clock is a direct target of miR‐124, and either restoration of miR‐124 or silencing of CLOCK can reduce the activation of NF‐κB. In conclusion, we suggest that as a target of glioma suppressor miR‐124, CLOCK positively regulates glioma proliferation and migration by reinforcing NF‐κB activity.