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Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA‐15)
Author(s) -
Thomason Lynsie A.M.,
Smithson Laura J.,
Hazrati Lili-Naz,
McLaurin JoAnne,
Kawaja Michael D.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.06.015
Subject(s) - phosphoprotein , neuroscience , astrocyte , human brain , alzheimer's disease , chemistry , biology , microbiology and biotechnology , central nervous system , phosphorylation , medicine , pathology , disease
To identify potential biomarkers associated with Alzheimer's disease (AD)‐like neuropathologies in the murine brain, we conducted proteomic analyses of neocortices from TgCRND8 mice. Here we found that phosphoprotein enriched in astrocytes 15 kDa (PEA‐15) is expressed at higher levels in the neocortical proteomes from 6‐month old TgCRND8 mice, as compared to non‐transgenic mice. Immunostaining for PEA‐15 revealed reactive astrocytes associated with the neocortical amyloid plaques in TgCRND8 mice and in post‐mortem human AD brains. This is the first report of increased phosphoprotein enriched in astrocytes (PEA‐15) expression in reactive astrocytes of an AD mouse model and human AD brains.