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Resveratrol modulates ATPase activity of liposome‐reconstituted ABCG1
Author(s) -
de Athayde Moncorvo Collado Alejandro,
Corbalán Natalia,
Homolya László,
Morero Roberto,
Minahk Carlos
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.06.001
Subject(s) - abcg1 , resveratrol , chemistry , transporter , atpase , liposome , microbiology and biotechnology , biochemistry , atp binding cassette transporter , biology , enzyme , gene
ABCG1 is a half‐sized transporter with an unquestionable importance in cholesterol homeostasis. So far, its expression and thus its activity was suggested to be regulated at transcriptional level by LXR and PPAR agonists including polyphenols. However, it is unknown whether there are other mechanisms of up‐regulation of ABCG1 activity. In the present work resveratrol was shown to induce a nearly twofold increase in ATPase activity of reconstituted ABCG1. Evidence is presented for the first time suggesting that resveratrol is able to activate ABCG1 activity by an alternative mechanism that involves an indirect interaction.