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Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora‐B
Author(s) -
Liu Ping,
Qi Meiyan,
Ma Chengbin,
Lao Guoying,
Liu Yu,
Liu Yan,
Liu Yingzi
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.05.065
Subject(s) - microrna , endometrial cancer , carcinogenesis , cancer research , hela , carcinoma , cell growth , biology , gene , cell , cancer , genetics
MicroRNAs negatively regulate target gene expression at the post‐transcriptional level during carcinogenesis. Recent advances revealed that the expression levels of several miRNAs are up‐ or down‐regulated in endometrial carcinoma (EC). Here we identify dysregulated miRNAs in EC and we elucidate the essential role of let‐7a. The expression of 86 miRNAs in EC was found to be different from adjacent normal endometrial tissues. Moreover, miR‐let‐7 members are down‐regulated in EC and let‐7 miRNAs are highly associated with endometrial cancer. A functional investigation revealed that let‐7a suppressed proliferation of HeLa cells by targeting Aurora‐B. Let‐7a also antagonizes Aurora‐B functions in promoting carcinoma cell proliferation by down‐regulating Aurora‐B protein level. Let‐7a could be applied for gene therapy against endometrial carcinogenesis.