Premium
Complex‐forming proteins escape the robust regulations of miRNA in human
Author(s) -
Das Jyotirmoy,
Chakraborty Sandip,
Podder Soumita,
Ghosh Tapash Chandra
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.05.062
Subject(s) - microrna , biology , gene , computational biology , human proteins , genetics
Most proteins carry out their functions by participating in protein complexes. Recently, miRNAs were identified as promising post‐transcriptional regulators that influence a large proportion of genes in higher eukaryotes. We aim to understand the role of miRNAs in the regulation of human proteins that are present in protein complexes. Here, we show that robust regulation by miRNA is absent in human complex‐forming proteins. Moreover, the numbers of miRNA hits cannot direct the evolutionary fate of complex‐forming proteins independently. However, the duplicated complex‐forming proteins having a severe effect on organismal fitness are profoundly targeted by miRNA, probably to reduce the chances of dosage imbalance.