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A role for the Ankyrin repeat containing protein Ankrd17 in Nod1‐ and Nod2‐mediated inflammatory responses
Author(s) -
Menning Maureen,
Kufer Thomas A.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.05.037
Subject(s) - nod2 , nod1 , innate immune system , pattern recognition receptor , ankyrin repeat , biology , immune system , inflammation , microbiology and biotechnology , acquired immune system , tlr4 , shigella flexneri , immunology , genetics , gene , escherichia coli
Innate immune responses induced by the pattern‐recognition receptors Nod1 and Nod2 play pivotal roles to combat infection and to instruct adaptive immunity. Here we identify Ankrd17 as a novel binding partner of Nod2 and show that its N‐terminal domain mediates Nod2 binding. Knock‐down and overexpression analysis revealed that Ankrd17 is functionally involved in Nod2‐ and Nod1‐mediated responses in human myeloid and epithelial cells. In HeLa cells Ankrd17 contributed to pro‐inflammatory responses induced by Shigella flexneri , however not to type I interferon responses induced by Sendai virus. In conclusion, this reveals a novel function for Ankrd17 in anti‐bacterial innate immune pathways.