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Genetic dissection of sodium and potassium transport along the aldosterone‐sensitive distal nephron: Importance in the control of blood pressure and hypertension
Author(s) -
Rossier Bernard C.,
Staub Olivier,
Hummler Edith
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.05.013
Subject(s) - aldosterone , amiloride , nephron , angiotensin ii , endocrinology , medicine , blood pressure , renin–angiotensin system , furosemide , epithelial sodium channel , kidney , sodium , chemistry , pharmacology , organic chemistry
In this review, we discuss genetic evidence supporting Guyton's hypothesis stating that blood pressure control is critically depending on fluid handling by the kidney. The review is focused on the genetic dissection of sodium and potassium transport in the distal nephron and the collecting duct that are the most important sites for the control of sodium and potassium balance by aldosterone and angiotensin II. Thanks to the study of Mendelian forms of hypertension and their corresponding transgenic mouse models, three main classes of diuretic receptors (furosemide, thiazide, amiloride) and the main components of the aldosterone‐ and angiotensin‐dependent signaling pathways were molecularly identified over the past 20 years. This will allow to design rational strategies for the treatment of hypertension and for the development of the next generation of diuretics.