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Functional interrogation of kinases and other nucleotide‐binding proteins
Author(s) -
Rosenblum Jonathan S.,
Nomanbhoy Tyzoon K.,
Kozarich John W.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.05.008
Subject(s) - kinase , function (biology) , signal transduction , interrogation , computational biology , nucleotide , biology , enzyme , microbiology and biotechnology , biochemistry , gene , history , archaeology
The largest mammalian enzyme family is the kinases. Kinases and other nucleotide‐binding proteins are key regulators of signal transduction pathways and the mutation or overexpression of these proteins is often the difference between health and disease. As a result, a massive research effort has focused on understanding how these proteins function and how to inhibit them for therapeutic benefit. Recent advances in chemical biological tools have enabled functional interrogation of these enzymes to provide a deeper understanding of their physiological roles. In addition, these innovative platforms have paved the way for a new generation of drugs whose properties have been guided by functional profiling.