Premium
The Evi5 family in cellular physiology and pathology
Author(s) -
Lim Yi Shan,
Tang Bor Luen
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.04.036
Subject(s) - cytokinesis , rab , cell cycle , biology , subfamily , microbiology and biotechnology , gtpase , regulator , gtpase activating protein , small gtpase , protein family , cell physiology , cell , genetics , signal transduction , cell division , gene , g protein
The Ecotropic viral integration site 5 (Evi5) and Evi5‐like (Evi5L) belong to a small subfamily of the Tre‐2/Bub2/Cdc16 (TBC) domain‐containing proteins with enigmatically divergent roles as modulators of cell cycle progression, cytokinesis, and cellular membrane traffic. First recognized as a potential oncogene and a cell cycle regulator, Evi5 acts as a GTPase Activating Protein (GAP) for Rab11 in cytokinesis. On the other hand, its homologue Evi5L has Rab‐GAP activity towards Rab10 as well as Rab23, and has been implicated in primary cilia formation. Recent genetic susceptibility analysis points to Evi5 as an important factor in susceptibility to multiple sclerosis. We discuss below the myriad of cellular functions exhibited by the Evi5 family members, and their associations with disease conditions.